Thermo Fisher Scientific GCNT7 Polyclonal Antibody
GCNT7 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. Human 및 Mouse 시료에 반응하며, Affinity chromatography로 정제됨. PBS buffer(50% glycerol) 형태로 제공되며 -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GCNT7 (Accession Q6ZNI0), corresponding to amino acid residues D324–I374 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854284 |
Product Specific Information
Antibody detects endogenous levels of total GCNT7.
Target Information
GCNT7 is a 430 amino acid glycosyltransferase localized to the Golgi apparatus. Other members of this family include GCNT1, GCNT2, GCNT3, GCNT4, and GCNT6.
GCNT1 plays a regulatory role in mucin-type O-glycan biosynthesis, serving as ligands in cell adhesion. Specifically, GCNT1 expression in leukocytes regulates synthesis of core 2 O-glycans that carry sialyl-Lewis x (sLex) oligosaccharides, which bind Selectin proteins with high affinity.
Downregulation of Selectin ligand expression inhibits tissue infiltration, making glycosyltransferase 14 family members potential drug targets for inflammatory disorders and other pathologies involving Selectin proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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