Thermo Fisher Scientific Robo3 Polyclonal Antibody
Robo3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, ELISA, IP 등 다양한 응용에 적합하며, 고순도 친화 크로마토그래피 정제. -20°C에서 보관하며 연구용으로만 사용 가능.
- 카탈로그번호
- RIG1-101AP
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Non-human primate, Panda |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to unique amino acid sequence on human RIG1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The ROBO3 gene belongs to the Roundabout (ROBO) family, which regulates neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are part of the immunoglobulin transmembrane receptor superfamily. SLIT proteins (1–3) act as ligands for ROBO proteins, and their interactions influence myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, vasculogenesis, and neurogenesis.
ROBO3 features an extracellular domain with five immunoglobulin-like loops and three fibronectin type III motifs, a transmembrane region, and a cytoplasmic tail with conserved signaling motifs (CC0, CC2, CC3). Unlike other ROBO family members, ROBO3 lacks the CC1 motif. It plays a key role in axonal navigation at the ventral midline of the neural tube. In mice, loss of Robo3 leads to failure of commissural axons to cross the midline in the spinal cord and hindbrain. Mutations in ROBO3 are associated with horizontal gaze palsy with progressive scoliosis (HGPPS), an autosomal recessive disorder characterized by absence of horizontal gaze, progressive scoliosis, and failure of corticospinal and somatosensory tracts to cross the medulla midline.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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