Thermo Fisher Scientific CD38 Recombinant Rabbit Monoclonal Antibody (6F10)
CD38 단백질을 표적하는 재조합 토끼 단클론 항체로, Western blot과 IHC(파라핀) 등에 적합. HEK293 세포에서 발현된 IgG 형태이며, 인간 CD38(aa 288-300) 유래 펩타이드로 면역화됨. 친화 크로마토그래피로 정제된 액상 제품으로 연구용으로만 사용.
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Applications
- Western Blot (WB): 1:500–1:5,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6F10 |
| Immunogen | A synthesized peptide derived from human CD38 (aa 288–300) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898290 |
Product Specific Information
This antibody has been tested in direct ELISA.
Target Information
CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes, and mediates apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD⁺ glycohydrolase or as a cell surface receptor.
Antibodies to CD38 are useful in:
- Subtyping of lymphomas and leukemias
- Detection of plasma cells (e.g., identification of myelomas)
- Marker for activated B and T cells
CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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