Thermo Fisher Scientific Acetyl-CBP/p300 (Lys1499, Lys1535) Polyclonal Antibody
CBP/p300 단백질의 Lys1499 및 Lys1535 아세틸화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot, IP, ICC/IF에 사용 가능. Human, Mouse, Non-human primate 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Immunoprecipitation (IP) | 1:50 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic acetylated peptide corresponding to residues surrounding Lys1535 of human CBP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 45 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979782 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene is ubiquitously expressed and involved in the transcriptional coactivation of many transcription factors. Initially identified as a nuclear protein binding to CREB, it plays essential roles in embryonic development, growth control, and homeostasis by linking chromatin remodeling to transcription factor recognition. The encoded protein has intrinsic histone acetyltransferase activity and serves as a scaffold for stabilizing transcription complex interactions. It acetylates both histone and non-histone proteins and shares high sequence similarity with p300 in several domains. Mutations cause Rubinstein-Taybi syndrome (RTS), and chromosomal translocations are linked to acute myeloid leukemia. Multiple transcript variants exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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