Thermo Fisher Scientific PIGR Polyclonal Antibody
Rabbit polyclonal antibody against human PIGR, validated for WB, IHC, and ICC/IF. High purity (>95%) via antigen affinity chromatography. Suitable for human, mouse, and rat samples. Supplied unconjugated in PBS with glycerol, for research use only.
- 카탈로그번호
- PA576848
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human PIGR (UniProt ID: P01833-1, antigen range: 1–764) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720575 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by antigen-specific chromatography. Purity >95% as verified by SDS-PAGE.
Target Information
Polymeric IgA and IgM are produced by B cells in the lamina propria beneath mucosal epithelial cells. The polymeric immunoglobulin receptor (pIgR) mediates transcellular transport of these immunoglobulins across epithelial layers. During transport, pIgR is cleaved to form the secretory component (SC), which protects immunoglobulin polymers from enzymatic degradation. The human pIgR gene is located on chromosome 1q31–q41 and encodes a 764-amino-acid protein with five immunoglobulin-like domains and a transmembrane region. SC and pIgR are essential for mucosal immunity, acting as molecular chaperones to maintain polymeric Ig integrity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(PA5-76848_PIGR_P01833-1_Rabbit.svg 및 PA5-76848_PIGR_P01833-1_Rabbit_PDP.jpeg)
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