Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI8A9), TrueMAB
ABCB1 단백질을 인식하는 마우스 단클론 항체로, 인간 시료에 반응합니다. 면역조직화학(IHC)용으로 검증되었으며, 무보존제 동결건조 형태로 제공됩니다. 재구성 및 결합 실험에 적합하며, 다약제 내성 연구에 활용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8A9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995–1280 of human ABCB1 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The ABCB1 gene encodes a membrane-associated protein belonging to the ATP-binding cassette (ABC) transporter superfamily. These proteins transport various molecules across cellular membranes and are categorized into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
ABCB1 is part of the MDR/TAP subfamily, involved in multidrug resistance. It functions as an ATP-dependent drug efflux pump with broad substrate specificity, reducing drug accumulation in resistant cells and contributing to anticancer drug resistance. It also acts as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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