Thermo Fisher Scientific Phospho-JAK3 (Tyr980, Tyr981) Polyclonal Antibody
JAK3 단백질의 Tyr980 및 Tyr981 인산화 부위를 인식하는 rabbit polyclonal 항체. Western blot 및 ELISA에 적합하며, 인간, 마우스, 랫트 시료에 반응. PBS/glycerol buffer에 보관되며 -20°C에서 안정적 유지.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around Y980 & Y981 of human Jak3 (NP_0002062) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855541 |
Product Specific Information
Immunogen sequence: KDYYVV
Target Information
Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors. Upon cytokine or interferon stimulation, JAKs are activated via phosphorylation at adjacent tyrosine residues, leading to STAT activation, dimerization, and nuclear translocation. Activated STAT proteins regulate transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for IFNγ receptor signaling, with JAK1 acting as an amplifier. Some studies suggest that Tyk2 and JAK3 may substitute for JAK2 under certain conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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