Thermo Fisher Scientific TCL1 Monoclonal Antibody (TCL1, 2078)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature (RT).
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at RT for 20 min.

Target Information

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, where chromosomal rearrangements place TCL1 near T-cell antigen receptor (TCR) regulatory elements (Virgilio et al., 1998).
In normal T cells, TCL1 is expressed in CD4-/CD8- cells but not in later stages of differentiation.
TCL1 functions as a coactivator of the cell survival kinase AKT (Laine et al., 2000).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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