Thermo Fisher Scientific TCL1 Monoclonal Antibody (TCL1, 2078)
Human TCL1 단백질을 인식하는 Mouse monoclonal antibody로, IHC(P) 및 Peptide Array에 사용 가능. Recombinant TCL1(aa 2-109)을 면역원으로 사용하며, Protein A/G로 정제된 액상 형태. -20°C 이하에서 보관, 연구용 전용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TCL1, 2078 |
| Immunogen | Recombinant human TCL1 protein fragment (around aa 2–109) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T-cell leukemia, where chromosomal rearrangements bring the TCL1 gene close to T-cell antigen receptor (TCR)-alpha or TCR-beta regulatory elements (Virgilio et al., 1998).
In normal T cells, TCL1 is expressed in CD4-/CD8- cells but not in cells at later stages of differentiation.
TCL1 functions as a coactivator of the cell survival kinase AKT (Laine et al., 2000).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: 8115-MSM1-P1ABX_TCL1A_TCL1_P56279-1_House_mouse.svg, 8115-MSM1-P1ABX_TCL1A_TCL1_P56279-1_House_mouse_PDP.jpeg)
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