Thermo Fisher Scientific beta Synuclein Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
• Positive Samples: Mouse eye, Mouse brain, Rat brain, Rat spinal cord
• Cellular Location: Cytoplasm

Target Information

Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates, they are encoded by three different genes. Synucleins have been implicated in major diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and breast cancer.

• In AD, a peptide derived from alpha-synuclein forms part of plaque amyloid.
• In PD, alpha-synuclein accumulates in Lewy bodies, and certain alleles are linked to familial PD cases.
• In breast cancer, increased gamma-synuclein expression correlates with disease progression.
  Synucleins also appear to be involved in membrane plasticity during development of the song control system in songbirds.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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