
Thermo Fisher Scientific beta Synuclein Polyclonal Antibody
Thermo Fisher Scientific의 beta Synuclein Polyclonal Antibody는 마우스 및 랫트 시료에 반응하는 토끼 유래 IgG 항체입니다. Western blot과 ELISA에 적합하며, 신경세포 내 시누클레인 연구에 활용됩니다. 액상 형태, 고순도, 안정적 보관 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–134 of human beta-Synuclein (NP_0010015021) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.01 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804492 |
Product Specific Information
- Immunogen sequence:
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA - Positive Samples: Mouse eye, Mouse brain, Rat brain, Rat spinal cord
- Cellular Location: Cytoplasm
Target Information
Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates, they are encoded by three different genes. Synucleins have been implicated in major diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and breast cancer.
- In AD, a peptide derived from alpha-synuclein forms part of plaque amyloid.
- In PD, alpha-synuclein accumulates in Lewy bodies, and certain alleles are linked to familial PD cases.
- In breast cancer, increased gamma-synuclein expression correlates with disease progression.
Synucleins also appear to be involved in membrane plasticity during development of the song control system in songbirds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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