Thermo Fisher Scientific DKC1 Polyclonal Antibody
Human DKC1 단백질을 인식하는 Thermo Fisher Scientific의 goat polyclonal antibody. Western blot과 IHC(P) 분석에 적합하며, 고순도(Ammonium sulfate precipitation)로 정제된 액상 형태. -20°C에서 보관하며 연구용으로 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 0.01 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (KRKRESESESDETPP) corresponding to the internal amino acids of DKC1 (aa 446–461) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10985014 |
Product Specific Information
- Predicted to react with mouse based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
The DKC1 gene belongs to the H/ACA snoRNPs gene family, which is involved in rRNA processing and modification. The H/ACA snoRNPs include NOLA1, NOLA2, and NOLA3 proteins. These proteins localize to nucleoli and coiled bodies in the nucleus. Deficiency of any of these proteins impairs 18S rRNA production and rRNA pseudouridylation.
The DKC1 protein is also part of the telomerase complex and is homologous to yeast Cbf5p and Drosophila Nop60B. Mutations in DKC1 cause X-linked dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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