Thermo Fisher Scientific TIM17 Polyclonal Antibody

Applications

• Western Blot (WB): 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 100%
Rat: 100%
Zebrafish: 79%

Target Information

Translocation of nuclear encoded preproteins into the mitochondrial matrix requires the coordinated action of the translocases Tom and Tim, which are located in the outer and inner mitochondrial membranes, respectively. The mitochondrial preprotein translocases of the outer membrane (Tom) is a multi-subunit complex consisting of import receptor subunits (Tom70, Tom37, Tom22, Tom20), small proteins (Tom7, Tom6, Tom5), and a structural component (Tom40).
The Tim channel imports nuclear-encoded mitochondrial preproteins and involves three proteins: Tim17, Tim23, and Tim44. Tim17 exists as two isoforms, Tim17a and Tim17b, differing in their C-terminal sequences, and both are ubiquitously expressed in fetal and adult tissues. Tim17 and Tim23 are integral membrane proteins forming the structural elements of the inner membrane channel, while Tim44 is a hydrophilic protein that recruits matrix-located Hsp70 to assist preprotein translocation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.