Thermo Fisher Scientific ZBED1 Monoclonal Antibody (OTI5A2), TrueMAB
인간 ZBED1 단백질을 인식하는 마우스 모노클로날 항체로, WB, IHC, Flow Cytometry에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 안정적 저장이 가능합니다. 연구용으로 DNA 복제 및 세포 증식 관련 단백질 분석에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A2 |
| Immunogen | Full-length human recombinant protein of human ZBED1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 plays a role in cell proliferation in human cells. At least 22 ribosomal proteins possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, which is required for nuclear localization and DNA binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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