Thermo Fisher Scientific Bim Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 1:25,000–1:50,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human BCL2L11/Bim.

Target Information

BIM belongs to the BCL-2 protein family. These proteins form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities.
The encoded protein contains a Bcl-2 homology domain 3 (BH3) and interacts with other BCL-2 family members such as BCL2, BCL2L1/BCL-X(L), and MCL1, functioning as an apoptotic activator.
Expression of this gene can be induced by nerve growth factor (NGF) and the forkhead transcription factor FKHR-L1, suggesting a role in neuronal and lymphocyte apoptosis.
Mouse transgenic studies indicate that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.