Thermo Fisher Scientific PON1 Polyclonal Antibody
Thermo Fisher Scientific의 PON1 Polyclonal Antibody는 인간 PON1 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot, IHC, Flow cytometry에 사용 가능하며, 고순도의 Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 연구용 전용 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 118–145 from the central region of human PON1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2541678 |
Target Information
The paraoxonase (PON) gene family in humans includes three members: PON1, PON2, and PON3, located on chromosome 7q21.3–22.1.
PON1 is synthesized primarily in the liver and secreted into plasma, where it associates with high-density lipoproteins (HDL).
It hydrolyzes active metabolites of organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon) and nerve agents such as sarin, soman, and VX.
PON1 polymorphisms are implicated in neurodegeneration and may act as an independent risk factor for Parkinson’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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