Thermo Fisher Scientific NEK8 Polyclonal Antibody
NEK8 단백질을 표적으로 하는 Thermo Fisher Scientific의 토끼 폴리클론 항체. Western blot 등 연구용으로 적합하며, 인간·마우스·랫트 반응성. 항원 친화 크로마토그래피로 정제, 고순도. 세포 주기 및 신장 발달 관련 연구에 활용 가능.
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Thermo Fisher Scientific NEK8 Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human NEK8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719565 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. Purity is >95% (by SDS-PAGE).
Target Information
NEK8 (serine/threonine kinase or NIMA-related kinase 8) is related to NIMA of Aspergillus nodulins and may play a role in cell cycle progression from G2 to M phase. It is part of a ciliary protein complex required for renal and cardiovascular development. NEK8 interacts with polycystin signaling pathways and may control the targeting of these ciliary proteins. It is required for renal tubular integrity and may regulate cytoskeletal structure and ciliary biogenesis.
Defects in NEK8 cause nephronophthisis type 9 (NPHP9) [MIM:613824], an autosomal recessive disorder leading to end-stage renal disease characterized by tubular modifications, basement membrane thickening, interstitial fibrosis, and medullary cysts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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