Thermo Fisher Scientific Human IL-4, Animal-Free Recombinant Protein, PeproTech
인간 유래 IL-4 재조합 단백질로, 동물 유래 성분이 없는 고순도(≥98%) 시약입니다. E. coli 발현 시스템에서 생산되며, TF-1 세포 증식을 유도하는 생물학적 활성을 가집니다. 면역조절 연구 및 세포 신호전달 연구에 적합합니다.
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Applications
ELISA (ELISA)
- Tested Dilution: Not specified
- Publications: View 1 publication
Functional Assay (Functional)
- Assay-dependent
- Publications: View publication
In vitro Assay (IV)
- Tested Dilution: Not specified
- Publications: View 88 publications
Miscellaneous PubMed (Misc)
- Tested Dilution: Not specified
- Publications: View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Human, Mouse |
| Expression System | E. coli |
| Amino Acid Sequence | MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS |
| Molecular Weight | 15.1 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | < 0.1 EU/µg |
| Activity | ED50 ≤ 0.2 ng/ml (specific activity ≥ 5 × 10⁶ units/mg, based on TF-1 cell proliferation) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.
This product is shipped at ambient temperature.
For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells.
It serves as a ligand for the interleukin-4 receptor, which also binds IL-13, leading to overlapping functions between IL-4 and IL-13.
STAT6 plays a key role in mediating the immune regulatory signaling of IL-4.
The IL-4 gene, along with IL-3, IL-5, IL-13, and CSF2, forms a cytokine gene cluster on chromosome 5q.
IL-4 is closely located near IL-13 and IL-5, and these genes are co-regulated by long-range elements spanning approximately 120 kb.
IL-4 delta 2 is a known splice variant of IL-4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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