Thermo Fisher Scientific eIF4E Polyclonal Antibody
Rabbit polyclonal antibody targeting human eIF4E for WB and IP applications. Recognizes residues 167–217 of eIF4E, predicted to react with multiple species. Supplied as liquid, unconjugated form, 0.2 mg/mL concentration, stored at 4°C. For research use...
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- A301154Ax (2개 옵션)
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 167 and 217 of human eukaryotic translation initiation factor 4E |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat, X. laevis, Bovine, and Rabbit
Target Information
eIF4E is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export.
All eukaryotic cellular mRNAs are blocked at their 5′ ends with the 7-methylguanosine cap structure, m7GpppX (where X is any nucleotide).
EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs.
It is a 24-kD polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F.
The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA–ribosome binding step of eukaryotic protein synthesis.
The other subunits of EIF4F are:
- EIF4A (50 kD): possesses ATPase and RNA helicase activities
- EIF4G (220 kD): scaffolding subunit of the complex
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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