Thermo Fisher Scientific FIR Polyclonal Antibody
FARP2(FIR) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 사용 가능. 인간 및 생쥐 반응성, 고순도 친화성 정제, PBS/glycerol 저장용액 포함. 연구용으로만 사용.
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Thermo Fisher Scientific FIR Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FARP2 (Accession O94887), corresponding to amino acid residues S344–L394 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853811 |
Product Specific Information
This antibody detects endogenous levels of total FIR.
Target Information
FARP2 (FERM, RhoGEF and pleckstrin domain-containing protein 2), also known as PLEKHC3 or FERM domain including RhoGEF (FIR), is a 1,545 amino acid protein containing one FERM domain, one DH domain, and two PH domains.
It exists as two alternatively spliced isoforms abundantly expressed in brain, lung, and testis, as well as in embryonic hippocampal and cortical neurons.
FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and regulates neurite remodeling of embryonic neurons.
Sema3A binding to neuropilin-1 induces dissociation of FARP2 from plexin-A1, activating Rac GEF activity critical for axon repulsion and suppression of neuronal adhesion.
Downregulation of FARP2 gene has been implicated in autism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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