Thermo Fisher Scientific DISC1 Recombinant Rabbit Monoclonal Antibody (4U5N1)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Positive test controls include: HeLa, MCF7, SH-SY5Y, Mouse brain, Mouse heart, Rat brain, Rat heart.
The target is usually found in the following locations: Cell junction, Cytoplasm, Centrosome, Cytoskeleton, Microtubule organizing center, Postsynaptic cell membrane, Postsynaptic density, Synapse.

Immunogen sequence:
MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS

Target Information

DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein that interacts with multiple proteins of the centrosome and cytoskeletal system. It is involved in neuronal functions dependent on proper cytoskeletal regulation, including neuronal migration, neurite architecture, and intracellular transport.

Regions of the brain expressing DISC1 include the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum, and paraventricular hypothalamus. Loss of DISC1 function results in altered structural organization and is associated with schizophrenia due to chromosomal translocations.

DISC1 encodes a large protein with a globular N-terminal and a helical C-terminal domain, both capable of protein-protein interactions. It interacts with proteins such as MIPT3, MAP1A, NUDEL, alpha-actinin 2, beta 4-spectrin, ATF-4, and ATF-5, implicating it in intracellular transport, neurite architecture, and neuronal migration. Decreased DISC1 expression in neurons accelerates neuronal integration and causes abnormal dendritic development, indicating its role in dendritic and synaptic formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.