Thermo Fisher Scientific IRAK1BP1 Polyclonal Antibody
IRAK1BP1 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 사용 가능하며, Human과 Mouse 시료 반응. 항원 친화 크로마토그래피로 정제된 고품질 항체로 연구용에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full-length fusion protein of Human IRAK1BP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635684 |
Product Specific Information
The antibody detects endogenous levels of total IRAK1BP1 protein.
Target Information
SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. It contains an intrinsically disordered region that associates with HSPA1 and HSPA8 and interacts directly with IRAK1 to promote RELA transcriptional activity.
SIMPL is a key component of the IRAK1-dependent TNFRSF1A signaling pathway, where TNF-alpha induces NF-kappa-B gene transcription and inhibits proinflammatory cytokines. Inactivation of SIMPL suppresses TNFRSF1A-induced NF-kappaB activity.
SIMPL localizes to the nucleus and cytoplasm and requires phosphorylation of Ser-56 and/or Ser-62 for full activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-50231_IRAK1BP1_Q5VVH5-1_Rabbit.svg, PA5-50231_IRAK1BP1_Q5VVH5-1_Rabbit_PDP.jpeg)
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