Thermo Fisher Scientific NUMB Polyclonal Antibody
NUMB 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 Immunocytochemistry에 사용 가능. 높은 특이성과 90% rat 서열 상동성. 항원 친화 크로마토그래피로 정제된 액상 항체로 연구용에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 0.2–0.5 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chicken, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to a C-terminal region of the murine NUMB protein sequence (between residues 600–653). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_568660 |
Product Specific Information
The target sequence has 90% sequence homology with rat.
Target Information
Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca²⁺ channel (VGCC) inhibitor or by Ca²⁺ chelator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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