Thermo Fisher Scientific PLOD2 Recombinant Rabbit Monoclonal Antibody (4E3L3)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:10,000-1:30,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4E3L3

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 260-380 of human PLOD2/LH2 (NP_000926.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PLOD2,uniProtId:O00469-1,ncbiNodeId:9606,antigenRange:260-380,antigenLength:737,antigenImageFileName:MA5-51272_PLOD2_O00469-1_Rabbit.svg,antigenImageFileNamePDP:MA5-51272_PLOD2_O00469-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.95 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_3094311

Product Specific Information

Immunogen sequence: ILLNYFGNYV PNSWTQDNGC TLCEFDTVDL SAVDVHPNVS IGVFIEQPTP FLPRFLDILL TLDYPKEALK LFIHNKEVYH EKDIKVFFDK AKHEIKTIKI VGPEENLSQA EARNMGMDFC R

Target Information

The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.