Thermo Fisher Scientific CD30 Monoclonal Antibody (Ber-H2), APC, eBioscience
인간 CD30 항원을 인식하는 Ber-H2 클론의 APC 결합 단일클론 항체로, Flow Cytometry에 최적화됨. 활성화된 T/B 림프구 및 CD30+ 림프종 검출에 사용. 4°C 암조건 보관, 동결 금지. 연구용 한정 제품.
- 카탈로그번호
- 17-0309-4x (2개 옵션)
- 판매단위
- pk
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Thermo Fisher Scientific CD30 Monoclonal Antibody (Ber-H2), APC, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.06 µg)/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | Ber-H2 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2762437 |
Additional Formats
- FITC
- PE
- PE-Cyanine7
- Super Bright 702
- Request custom conjugation
Product Specific Information
The Ber-H2 monoclonal antibody reacts with human CD30, a 120 kDa transmembrane glycoprotein of the TNFR superfamily. CD30 is expressed on activated T and B lymphocytes, but not on resting lymphocytes. It is also found on certain lymphomas, embryonal carcinomas, and virus-infected lymphocytes (HIV, HTLV, EBV). Interaction with its ligand CD30L leads to activation of NF-kappaB and regulation of apoptosis.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated and tested by flow cytometry on stimulated human peripheral blood cells at 5 µL (0.06 µg)/test.
A test corresponds to staining a 100 µL cell sample (10^5–10^8 cells/test).
Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser
Target Information
CD30 (Ki-1, TNF Receptor Superfamily Member 8) is a type I transmembrane glycoprotein originally identified on Hodgkin’s and Reed-Sternberg cells. CD30L (CD153) is its ligand, mediating cell proliferation, activation, differentiation, and apoptosis. It plays a key role in Hodgkin’s disease and other CD30+ lymphomas, acting as a costimulatory molecule in thymic negative selection. CD30 expression occurs on activated T and B cells, virus-infected lymphocytes, and some non-Hodgkin’s lymphomas. The soluble form (sCD30) reflects Th2 immune response. TRAF2 and TRAF5 interact with CD30 to activate NF-kappaB signaling. CD30 is a positive regulator of apoptosis and limits autoreactive CD8 effector T cell proliferation. Two alternatively spliced transcript variants exist. CD30 is expressed by mononuclear cells in Hodgkin’s lymphoma, Reed-Sternberg cells, and most Anaplastic Large Cell Lymphomas (ALCL), as well as embryonal carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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