Thermo Fisher Scientific PRTFDC1 Polyclonal Antibody
PRTFDC1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 사용 가능. 인간 시료에 반응하며, 고순도의 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관되며 -20°C에서 안정적. 종양 억제 관련 연구에 유용.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length fusion protein of human PRTFDC1 (aa 1–225, UniProt ID: Q9NRG1-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2636776 |
Product Specific Information
This antibody detects endogenous levels of total PRTFDC1 protein.
Target Information
Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event. CpG islands in the PRTFDC1 promoter can be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth, while knockdown promoted cell proliferation, suggesting PRTFDC1 functions as a tumor suppressor gene. At least three isoforms of PRTFDC1 are known.
Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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