Thermo Fisher Scientific COMMD10 Polyclonal Antibody

Thermo Fisher Scientific COMMD10 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:100

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total COMMD10 protein.

Target Information

The COMMD family represents a group of evolutionarily conserved proteins that share a common COMM domain at their extreme C-terminus, providing an interface for protein-protein interactions.
COMMD10 (COMM domain containing 10), also known as PTD002 or HSPC305, is a 202 amino acid protein belonging to the COMMD family and contains one COMM domain.
The COMMD10 gene maps to human chromosome 5, which contains approximately 181 million base pairs and comprises nearly 6% of the human genome.
Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
COMMD10 may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237) and may down-regulate activation of NF-kappa-B.

Usage Notes

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.