Thermo Fisher Scientific CXCR4 Monoclonal Antibody (2H5)
CXCR4 단백질을 인식하는 Mouse monoclonal antibody (Clone 2H5). Western blot 및 ELISA에 적합하며, 인간 시료 반응성. Affinity chromatography로 정제된 액상 시약으로, PBS(pH 7.4)에 보존제 없이 제공. 연구용 전용.
- 카탈로그번호
- H00007852-M01
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CXCR4 Monoclonal Antibody (2H5)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 1–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2H5 |
| Immunogen | CXCR4 (AAH20968, 1–46 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MEGISIYTSD NYTEEMGSGD YDSMKEPCFR EENANFNKIF LPTIYS
Target Information
CXCR4 (also known as Fusin, LESTR, HUMSTR) is a G-protein-coupled chemokine receptor with seven membrane-spanning domains. It functions as a co-receptor for X4 HIV-1 entry into CD4+ cells and also mediates HIV-2 binding and fusion. CXCR4 serves as the receptor for the chemokine CXCL12/SDF-1, triggering intracellular calcium increase and MAPK1/MAPK3 activation. It also acts as a receptor for extracellular ubiquitin, influencing calcium and cAMP signaling. CXCR4 plays roles in hematopoiesis, cardiac and vascular development, and neuronal survival. Antibodies to CXCR4 can block HIV-1 and HIV-2 infection of human target cells. The N-terminal domain and second extracellular loop are key HIV binding sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.