
Thermo Fisher Scientific CXCR4 Monoclonal Antibody (2H5)
CXCR4 단백질을 인식하는 Mouse monoclonal antibody (Clone 2H5). Western blot 및 ELISA에 적합하며, 인간 시료 반응성. Affinity chromatography로 정제된 액상 시약으로, PBS(pH 7.4)에 보존제 없이 제공. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 1–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2H5 |
| Immunogen | CXCR4 (AAH20968, 1–46 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MEGISIYTSD NYTEEMGSGD YDSMKEPCFR EENANFNKIF LPTIYS
Target Information
CXCR4 (also known as Fusin, LESTR, HUMSTR) is a G-protein-coupled chemokine receptor with seven membrane-spanning domains. It functions as a co-receptor for X4 HIV-1 entry into CD4+ cells and also mediates HIV-2 binding and fusion. CXCR4 serves as the receptor for the chemokine CXCL12/SDF-1, triggering intracellular calcium increase and MAPK1/MAPK3 activation. It also acts as a receptor for extracellular ubiquitin, influencing calcium and cAMP signaling. CXCR4 plays roles in hematopoiesis, cardiac and vascular development, and neuronal survival. Antibodies to CXCR4 can block HIV-1 and HIV-2 infection of human target cells. The N-terminal domain and second extracellular loop are key HIV binding sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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