Thermo Fisher Scientific TXK Polyclonal Antibody
TXK 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF 등 다양한 응용 가능. Human 및 Mouse 반응성. 1 mg/mL 농도의 액상형, 친화 크로마토그래피로 정제. 연구용으로만 사용.
- 카탈로그번호
- PA599845
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TXK (Accession P42681), corresponding to amino acid residues I30–V80 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818778 |
Product Specific Information
Antibody detects endogenous levels of total TXK.
Target Information
TXK, along with the close relatives BMS, ITK, and BTK, signal downstream of antigen receptors and other receptor types. All members of the family contain SH3 and SH2 domains and, except for Txk and Dsrc28C, also contain pleckstrin homology (PH) and Tec homology (TH) domains in their amino termini. Four alternatively spliced forms of Tec are expressed broadly in hematopoietic cells and hepatocytes. The Emt gene product associates with CD28 and becomes activated after CD28 ligation. Btk is essential for proper B cell development, and mutations in Btk cause X-linked agammaglobulinemia (Bruton’s disease). The Bmx protein shares high homology with Btk and is highly expressed in the heart. Txk expression is T cell-specific, while the Drosophila Tec homolog Dsrc28C is developmentally regulated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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