Thermo Fisher Scientific Kalirin Polyclonal Antibody
Kalirin 단백질을 검출하기 위한 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 랫트 반응성. 1 mg/mL 농도의 액상 제품으로 -20°C 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KALRN (Accession O60229), corresponding to amino acid residues F1657–C1707 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818776 |
Product Specific Information
Antibody detects endogenous levels of total KALRN.
Target Information
HAP1 (huntingtin-associated protein 1) binds to huntingtin, a protein containing a polyglutamine region. When the number of glutamine repeats exceeds 35, huntingtin leads to Huntington’s disease (HD). HAP1’s binding ability is enhanced by the expanded polyglutamine region. It shows neuronal localization and moves with huntingtin in nerve fibers. HAP1 is primarily expressed in the brain, especially in the olfactory bulb and brain stem. In mice, HAP1 localizes to membrane-bound organelles, including endosomes, tubulovesicular structures, and budding vesicles in neurons. Duo (HAPIP) binds HAP1 and may play a role in vesicle trafficking and cytoskeletal function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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