Thermo Fisher Scientific Chitotriosidase Monoclonal Antibody (397504)

Applications

Tested Dilution

Publications

Immunoprecipitation (IP)

25 µg/mL

-

Neutralization (Neu)

56 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

397504

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Chitotriosidase/CHIT1 Ala22-Asn466 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Chitotriosidase,uniProtId:Q13231-1,ncbiNodeId:9606,antigenRange:22-466,antigenLength:466,antigenImageFileName:MA5-24132_Chitotriosidase_Q13231-1_House_mouse.svg,antigenImageFileNamePDP:MA5-24132_Chitotriosidase_Q13231-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2607953

Product Specific Information

In direct ELISAs, no cross-reactivity with recombinant human CHI3L1 is observed.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.