Thermo Fisher Scientific Aminoacylase Monoclonal Antibody (475730)

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL

Immunoprecipitation (IP)

• Tested Dilution: 25 µg/mL

Product Specifications

Product Specific Information

• In Western blots, no cross-reactivity with recombinant human ACY1 is observed.
• Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is involved in the catabolism and salvage of acylated amino acids.
The gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), where expression is often reduced or undetectable.
Human aminoacylase-1 shows high homology with the porcine counterpart and represents the first member of a new family of zinc-binding enzymes.
Mutations in ACY1 cause aminoacylase-1 deficiency, a metabolic disorder characterized by CNS defects and increased urinary excretion of N-acetylated amino acids.
Alternative splicing produces multiple transcript variants, and read-through transcription occurs between ACY1 and ABHD14A. A pseudogene is identified on chromosome 18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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