Thermo Fisher Scientific FLIP Monoclonal Antibody (7A3D12)
FLIP 단백질을 표적하는 마우스 모노클로날 항체로, Western blot, IHC, Flow cytometry, ELISA에 적합. 고순도 Protein G 정제 및 1 mg/mL 농도. 인간 및 생쥐 반응성. 세포 사멸 관련 연구용으로 최적화.
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Thermo Fisher Scientific FLIP Monoclonal Antibody (7A3D12)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7A3D12 |
| Immunogen | Purified recombinant fragment of human CFLAR (AA: 100–251) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787303 |
Product Specific Information
MA5-31679 has been tested in indirect ELISA.
Target Information
FLIP (CFLAR) is an apoptosis regulator protein acting as a crucial link between cell survival and cell death pathways in mammalian cells. It inhibits TNFRSF6-mediated apoptosis, with a proteolytic fragment (p43) retained in the death-inducing signaling complex (DISC), blocking recruitment and processing of caspase-8. Full-length and shorter isoforms can either induce or reduce TNFRSF-triggered apoptosis. This protein lacks enzymatic (caspase) activity.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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