Thermo Fisher Scientific Phospho-C/EBP alpha (Ser21) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

• It is not recommended to aliquot this antibody.
• This antibody is not cross-reactive with other phosphorylated C/EBP isoforms.

Target Information

The C/EBP (CCAAT/enhancer binding protein) family of transcription factors — alpha, beta, delta, and epsilon — are widely expressed proteins found in various tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L)KXEP.
One of the major roles of these transcription factors is metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of adipose cells.
Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation sites and display different functions in gene regulation. From a neurological standpoint, C/EBPs have been implicated in mediating nerve growth factor signaling, altering synaptic plasticity, and modulating inflammatory responses in Alzheimer’s disease patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.