
Thermo Fisher Scientific Phospho-C/EBP alpha (Ser21) Polyclonal Antibody
인간 및 생쥐 시료에서 C/EBPα의 Ser21 인산화 형태를 검출하는 폴리클로날 항체입니다. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 방부제 없이 액상 형태로 제공되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer21 of human C/EBPα |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 225 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10984218 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other phosphorylated C/EBP isoforms.
Target Information
The C/EBP (CCAAT/enhancer binding protein) family of transcription factors — alpha, beta, delta, and epsilon — are widely expressed proteins found in various tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L)KXEP.
One of the major roles of these transcription factors is metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of adipose cells.
Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation sites and display different functions in gene regulation. From a neurological standpoint, C/EBPs have been implicated in mediating nerve growth factor signaling, altering synaptic plasticity, and modulating inflammatory responses in Alzheimer’s disease patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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