Thermo Fisher Scientific PRPK Polyclonal Antibody
Human PRPK 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TP53RK. Recombinant protein control fragment (Product # RP-89811) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789700 |
Product Specific Information
Immunogen sequence:
AAVIKHRFPK GYRHPALEAR LGRRRTVQEA RALLRCRRAG ISAPVVFFVD YASNCLYMEE IEGSVTVRDY IQSTMETEKT PQGLSNLAKT IGQV
Target Information
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914).
The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914).
TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP.
Atypical protein kinase that phosphorylates Ser-15 of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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