Thermo Fisher Scientific CD31 Monoclonal Antibody (LCI-9)
돼지 CD31(PECAM-1)을 인식하는 Mouse Monoclonal Antibody로, IHC(F) 및 유세포분석(Flow Cytometry)에 사용 가능. 비결합형(Unconjugated) 액상 형태이며, 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
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Applications
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Pig |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LCI-9 |
| Immunogen | Porcine CD31/human IgGFc fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Tissue culture supernatant |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2161016 |
Product Specific Information
Mouse anti Pig CD31 antibody, clone LCI-9 recognizes porcine Platelet Endothelial Cell Adhesion Molecule, also known as CD31 or PECAM-1.
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling via dual immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Upon phosphorylation by associated kinases, these motifs provide docking sites for protein-tyrosine phosphatases.
CD31 is ubiquitously expressed within the vascular compartment, primarily at junctions between adjacent cells. The N-terminal Ig-like domain mediates homophilic binding, crucial for cell-cell interactions.
This multifunctional molecule plays roles in:
- Modulation of integrin-mediated cell adhesion
- Transendothelial migration
- Angiogenesis
- Apoptosis
- Negative regulation of immunoreceptor signaling
- Autoimmunity and macrophage phagocytosis
- IgE-mediated anaphylaxis and thrombosis
CD31 is a key regulatory molecule in the vascular system.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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