Thermo Fisher Scientific ErbB4 Monoclonal Antibody (H4.72.8 (Ab72))
HER4(ErbB4) 단백질을 검출하기 위한 Mouse monoclonal antibody로, Human 및 Mouse 시료에 반응합니다. Western blot, Flow cytometry 등 다양한 응용에 적합하며, Protein A 정제 및 PBS 기반 buffer로 안정화되어 있습니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific ErbB4 Monoclonal Antibody (H4.72.8 (Ab72))
Thermo Fisher Scientific ErbB4 Monoclonal Antibody (H4.72.8 (Ab72))
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:50–1:500 | 2 publications |
| Immunohistochemistry (IHC) | – | 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | – | 1 publication |
| Immunocytochemistry (ICC/IF) | – | 3 publications |
| Flow Cytometry (Flow) | 0.5 µg/test | 1 publication |
| Immunoprecipitation (IP) | – | 1 publication |
| Neutralization (Neu) | – | 10 publications |
| in situ PLA (PLA) | – | 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Ferret, Human, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H4.72.8 (Ab72) |
| Immunogen | Extracellular domain of recombinant human c-erbB-4/HER-4 oncoprotein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10990351 |
Additional Formats
Product Specific Information
MA5-13016 targets HER-4 in WB and FACS applications and shows reactivity with Human and Mouse samples.
The immunogen is the extracellular domain of recombinant human c-erbB-4/HER-4 oncoprotein.
Target Information
Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine kinase family, which includes EGFR, ERBB2, and ERBB3.
ERBB4 binds and is activated by neuregulins and other ligands, inducing cellular responses such as mitogenesis and differentiation.
It mediates signal transduction processes regulating metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, apoptosis, and differentiation.
ERBB4 is predominantly expressed in several breast carcinoma cell lines and normal tissues such as skeletal muscle, heart, pituitary, brain, and cerebellum.
High mRNA levels are observed in breast tumor cell lines T47-D, MDA-MB-453, BT-474, and H3396; intermediate levels in MCF-7, MDAMB-330, and MDA-MB-361; and low or absent expression in MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.
Elevated ERBB4 levels in certain tumor cell lines suggest its potential role in malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.