Thermo Fisher Scientific ErbB4 Monoclonal Antibody (H4.72.8 (Ab72)), Biotin
ErbB4(HER4) 단백질을 표적하는 Biotin 결합 Mouse monoclonal antibody. Western blot, IHC, ICC, Flow, IP, Neutralization 등 다양한 응용에 적합. Human에 반응하며 Protein A로 정제됨. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:50–1:500 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Immunocytochemistry (ICC/IF) | – | View 3 publications |
| Flow Cytometry (Flow) | Assay-dependent | View 1 publication |
| Immunoprecipitation (IP) | – | View 1 publication |
| Neutralization (Neu) | – | View 9 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Ferret, Human, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H4.72.8 (Ab72) |
| Immunogen | Extracellular domain of recombinant human c-erbB-4/HER-4 oncoprotein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10984090 |
Additional Formats
Product Specific Information
MA5-13013 targets HER-4 in WB and FACS applications and shows reactivity with Human samples.
The immunogen is the extracellular domain of recombinant human c-erbB-4/HER-4 oncoprotein.
Target Information
Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine kinase subfamily, including EGFR, ERBB2, and ERBB3. ERBB4 binds and is activated by neuregulins and other factors, inducing cellular responses such as mitogenesis and differentiation.
ErbB4 acts as a receptor for heregulin and mediates HGL-stimulated tyrosine phosphorylation. It regulates key cellular processes including metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, apoptosis, and differentiation.
Expression of ErbB4 is high in several breast carcinoma cell lines and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Elevated ErbB4 levels in certain tumor cell lines suggest a potential role in malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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