Thermo Fisher Scientific Human VPS53 Synthetic Peptide
인간 VPS53 단백질의 C-말단 18개 아미노산 서열을 기반으로 한 합성 펩타이드. PA5-20548 항체의 블로킹 펩타이드로 사용 가능. 순도 높은 액상 형태로 제공되며 PBS 버퍼에 0.1% BSA 및 0.02% sodium azide 포함. 연구용으로만 사용 가능.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the carboxy terminus of human VPS53.
PEP-0668 can be used as a blocking peptide with polyclonal antibody PA5-20548.
Target Information
The sorting of acid hydrolases to lysosomes relies on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex, which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins.
VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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