Thermo Fisher Scientific TLR1 Polyclonal Antibody
TLR1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용에 적합합니다. 인간, 생쥐, 랫드 반응성이 있으며, 고순도 Protein A 정제 및 안정적인 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:25 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human TLR1, amino acids 101–200 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TLR1 protein is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) expressed on infectious agents and mediate cytokine production necessary for effective immunity.
The TLR family in mammals consists of transmembrane proteins characterized by multiple leucine-rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. TLR1 interacts with TLR2, and co-expression enhances NF-κB activation in response to synthetic lipopeptides. They recognize lipid configurations of native mycobacterial lipoproteins and several tri-acylated lipopeptides.
Different transcript lengths may result from alternative polyadenylation sites or splicing events for the TLR1 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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