Thermo Fisher Scientific Calnexin Monoclonal Antibody (AF18), Alexa Fluor 555

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1–10 µg/mL

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• Alexa Fluor 647
• Request custom conjugation

Product Specific Information

MA3-027-A555 detects calnexin from human and mouse tissues.
The immunogen is a focus human hepatoma cell lysate.

Target Information

Calnexin (also known as IP90, p88, and p90) is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER). It functions as a molecular chaperone, assisting in the proper folding and assembly of polypeptides into multisubunit proteins.

Calnexin associates with MHC class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes. It retains incompletely or improperly folded proteins in the ER.

Unlike soluble ER resident proteins that contain the KDEL sequence for ER retention, calnexin lacks this motif but contains positively charged cytosolic residues that ensure ER localization.
It comprises a large luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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