Thermo Fisher Scientific Human SIRT1 Synthetic Peptide
Human SIRT1 단백질의 N-말단 19개 아미노산 서열에 해당하는 합성 펩타이드. SIRT1 항체(PA5-20964)와 함께 블로킹 펩타이드로 사용 가능. 액상 형태로 제공되며 PBS 버퍼(pH 7.2, 0.1% BSA) 내 보관. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 19 amino acids near the amino terminus of human SIRT1.
PEP-1078 can be used as a blocking peptide with polyclonal antibody PA5-20964.
Target Information
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis, and autophagy.
SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression.
It is essential in skeletal muscle cell differentiation and, in response to low nutrients, mediates the inhibitory effect on skeletal myoblast differentiation, which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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