Thermo Fisher Scientific Human CtIP Synthetic Peptide
휴먼 CtIP 단백질의 중심부 15개 아미노산으로 구성된 합성 펩타이드. 항체 PA5-20963의 블로킹 펩타이드로 사용 가능. BRCA1 상호작용 연구 및 DNA 손상 반응 연구에 활용. 연구용으로만 사용.
- 카탈로그번호
- PEP1077
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the center of human RBBP8.
PEP-1077 can be used as a blocking peptide with polyclonal antibody PA5-20963.
Target Information
CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein), suggesting a role in transcription.
Studies have shown that CtIP also interacts with BRCA1 protein through the C-terminus BRCT domains, indicating that CtIP is a potential tumor suppressor.
The CtIP-BRCA1 interaction can be disrupted by DNA-damaging agents including UV or gamma-irradiation.
Li et al. (Nature 406, 210–215, 2000) demonstrated that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites prevents BRCA1 dissociation from CtIP, leading to persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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