Thermo Fisher Scientific TIM-1 Monoclonal Antibody (219211), PE
PE 형광 표지된 사람 TIM-1 (CD365) 단클론 항체로, Flow Cytometry에 적합합니다. 마우스 IgG2b 아이소타입이며, 인간 TIM-1에 특이적으로 반응하고 마우스 및 기타 TIM 단백질과 교차 반응하지 않습니다. 4°C에서 암소 보관하며, 연구용으로만 사용됩니다.
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Applications
- Flow Cytometry (Flow): 10 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 219211 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human TIM-1/KIM-1/HAVCR (Ser21–Thr288) |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Storage Conditions | 4°C, store in the dark, Do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_2606142 |
Product Specific Information
This antibody does not cross-react with recombinant mouse TIM-1, mouse TIM-2, or human TIM-3.
Target Information
CD365, also known as T-cell immunoglobulin and mucin domain 1 (TIM-1), is a type I surface glycoprotein with an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail. Its endogenous ligand is TIM-4.
CD365 serves as a receptor or co-receptor for several viruses, including hepatitis A and C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses, binding via phosphatidylserine on viral envelopes.
Polymorphisms in the human CD365 (HAVCR1) gene are associated with susceptibility and disease severity. CD365 also plays a role in T-cell co-stimulation and is primarily expressed in epithelial cells, with high expression in A549, 769-P, and Caco-2 cell lines. Soluble forms can arise through proteolytic cleavage by metalloproteinases.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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