Thermo Fisher Scientific PACS1 Polyclonal Antibody
인체 PACS1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. IHC(P) 및 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 용액 형태로 제공되며 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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- PA558589
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Thermo Fisher Scientific PACS1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PACS1 (Product #RP-97484) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645160 |
Product Specific Information
- Immunogen sequence:
DTTSPMELAA LEKIKSTWIK NQDDSLTETD TLEITDQDMF GDASTSLVVP EKVKTPMKSS KTDLQGSASP SKVEGVHTPR QKRSTPLKER QLSKPLSE - Ortholog sequence identity:
Mouse - 96%, Rat - 97%
Target Information
PACS-1 (CRA_a) is a 963 amino acid regulatory protein involved in protein trafficking and belongs to the PACS family. It controls subcellular localization of trans-Golgi network (TGN) membrane proteins containing acidic cluster sorting motifs. PACS-1 participates in HIV-1 Nef-mediated removal of MHC-I from the cell surface to the TGN, aiding immune evasion. It also mediates endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by linking their acidic-cluster cytoplasmic domains with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated pits. PACS-1 is typically localized in the Golgi apparatus, trans-Golgi network, and paranuclear region, and is ubiquitously expressed across tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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