Thermo Fisher Scientific GSDMD Polyclonal Antibody
Rabbit polyclonal antibody targeting human Gasdermin-D (GSDMD). Suitable for immunoprecipitation applications. Supplied as a liquid, 1 mg/mL concentration. Recommended storage at 4°C. For research use only.
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Applications
- Immunoprecipitation (IP): 8–15 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A region between residue 225 to 275 of human Gasdermin-D |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
GSDMD (gasdermin-D) promotes pyroptosis in response to microbial infection and danger signals. It is produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical and non-canonical inflammasome activators (such as cytosolic LPS).
After cleavage, GSDMD moves to the plasma membrane where it binds to inner leaflet lipids including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-biphosphate, phosphatidylinositol (3,4,5)-biphosphate, phosphatidic acid, and phosphatidylserine.
GSDMD also exhibits bactericidal activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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