Thermo Fisher Scientific GSDMD Polyclonal Antibody
Rabbit에서 유래한 GSDMD 폴리클로날 항체로 Western blot 및 Immunoprecipitation에 적합. 인간 Gasdermin-D의 434–484번 잔기 영역을 면역원으로 사용. 1 mg/mL 농도의 액상 형태로 제공되며, 4°C에서 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 20 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A region between residue 434 to 484 of human Gasdermin-D |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
GSDMD (gasdermin-D) promotes pyroptosis in response to microbial infection and danger signals. It is produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, GSDMD translocates to the plasma membrane where it binds strongly to inner leaflet lipids including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate, phosphatidylinositol (3,4,5)-trisphosphate, phosphatidic acid, and phosphatidylserine. GSDMD also exhibits bactericidal activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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