Thermo Fisher Scientific PRTN3 Monoclonal Antibody (OTI5B9), TrueMAB
인간 PRTN3 단백질(아미노산 28-248)에 특이적인 단클론 항체로 Western blot에 최적화됨. Mouse IgG2b 아이소타입, 비결합형, 동결건조 형태. 친화 크로마토그래피로 정제되어 높은 순도 보장. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 28–248 of human PRTN3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
PRTN3 is a serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246).
By cleaving and activating receptor F2RL1/PAR-2, it enhances endothelial cell barrier function and vascular integrity during neutrophil transendothelial migration (PubMed:23202369).
It may also play a role in neutrophil transendothelial migration, possibly when associated with CD177 (PubMed:22266279).
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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