Thermo Fisher Scientific c-Myc Monoclonal Antibody (9E10), FITC
FITC 형광 표지된 c-Myc 단일클론 항체로 인간 및 생쥐 시료에 반응합니다. IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합하며, 고순도 정제된 액상 형태로 공급됩니다. 세포 증식 및 종양 관련 연구에 유용합니다.
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Thermo Fisher Scientific c-Myc Monoclonal Antibody (9E10), FITC
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 1 publication |
| Flow Cytometry (Flow) | - | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9E10 |
| Immunogen | A 32 amino acid synthetic peptide (aa 408–439) derived from the C-terminus of the human c-myc protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533009 |
Additional Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 555
- Alexa Fluor 647
- DyLight 488
- HRP
- Request custom conjugation available
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression. c-Myc activation is common in various tumor cells and is essential for vasculogenesis and angiogenesis during tumor development.
Amplification of the c-Myc gene has been found in several human cancers including lung, breast, and colon carcinomas. Translocation of the c-myc locus to immunoglobulin loci is associated with Burkitt’s lymphoma and other B-cell lymphoproliferative disorders. Aberrant expression of c-myc occurs in tumors of diverse origins such as colorectal, gastric, hepatic, ovarian, and hematopoietic neoplasms.
Antibodies against c-myc epitopes recognize Myc-tagged fusion proteins at either amino or carboxy termini.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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