Thermo Fisher Scientific Cyclophilin A VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1329)
Cyclophilin A(VHH-8His-Cys-tag) 재조합 알파카 단일클론 항체로 인간 PPIA 단백질을 표적화합니다. Western blot 및 ELISA에 적합하며, CHO 세포에서 발현된 액상 항체입니다. 금속 킬레이트 크로마토그래피로 정제되었으며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
Western Blot (WB)
- Assay-dependent
ELISA
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Alpaca / VHH |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SAA1329 |
| Immunogen | Recombinant Human PPIA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Compatible with Direct ELISA
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents—cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs), and those that bind cyclosporin A are called cyclophilins (CyP).
Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a calcium and calmodulin-dependent protein phosphatase involved in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506.
Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase), accelerating protein folding by catalyzing slow steps in the rearrangement of proline-containing proteins. Within the cyclophilin family, several homologous proteins exist, including CyPA, CyPB, and CyPC. CyPA (CyP-18) is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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