Thermo Fisher Scientific PELI1 Monoclonal Antibody (OTI1A8), TrueMAB
인간 PELI1 단백질(아미노산 1–245)을 항원으로 제작된 Mouse IgG1 단클론 항체. Western blot에 최적화(1:2,000 희석). 액상 형태, 1 mg/mL 농도, PBS/BSA/글리세롤 버퍼. Toll-like receptor 경로 연구용 E3 유비퀴틴 리가아제 분석에 적합.
- 판매단위
- pk
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Thermo Fisher Scientific PELI1 Monoclonal Antibody (OTI1A8), TrueMAB
Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–245 of human PELI1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways leading to activation of MAP kinases and transcription factors.
Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4–IRAK–TRAF6 complex, resulting in activation of NF-Kappa-B.
Like other members of the Pellino family, Pellino 1 catalyzes polyubiquitination of IRAK1 and is activated via phosphorylation by IRAK1, IRAK4, IKK-epsilon, and TBK1. Its activity is also modulated via ubiquitination and sumoylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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